Small conductance Ca 2 + - activated K + channels modulate 2 action potential - induced Ca 2 + transients in hippocampal neurons . 3 4
نویسندگان
چکیده
4 Raffaella Tonini, Teresa Ferraro, Marisol Sampedro-Castañeda, Anna Cavaccini, Martin 5 Stocker, Christopher D. Richards and Paola Pedarzani* 6 7 Research Department of Neuroscience, Physiology and Pharmacology, University College London, 8 London, UK. 9 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy. 10 11 *To whom correspondence should be addressed at: 12 Research Department of Neuroscience, Physiology and Pharmacology 13 University College London, Gower Street, London WC1E 6BT, United Kingdom 14 Tel.: +44-(0)20-7679 7744 15 E-mail: [email protected] 16 17 18 Author Contributions: MS, CDR and PP conceived the study, designed and supervised the 19 experiments; RT, TF, MS-C, AC, CDR and PP performed the experiments and analyzed the data; 20 RT, MS, CDR and PP wrote the manuscript. 21 22 23 Running Head: SK channel modulate spike-induced Ca transients 24 25 26 Articles in PresS. J Neurophysiol (December 19, 2012). doi:10.1152/jn.00346.2012
منابع مشابه
Small-conductance Ca -activated K channels modulate action potential-induced Ca transients in hippocampal neurons
Tonini R, Ferraro T, Sampedro-Castañeda M, Cavaccini A, Stocker M, Richards CD, Pedarzani P. Small-conductance Ca activated K channels modulate action potential-induced Ca transients in hippocampal neurons. J Neurophysiol 109: 1514–1524, 2013. First published December 19, 2012; doi:10.1152/jn.00346.2012.—In hippocampal pyramidal neurons, voltage-gated Ca channels open in response to action pote...
متن کاملSmall-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.
In hippocampal pyramidal neurons, voltage-gated Ca(2+) channels open in response to action potentials. This results in elevations in the intracellular concentration of Ca(2+) that are maximal in the proximal apical dendrites and decrease rapidly with distance from the soma. The control of these action potential-evoked Ca(2+) elevations is critical for the regulation of hippocampal neuronal acti...
متن کاملEnhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).
The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not been explicitly tested for 2 reasons: 1) there are, at present, no selective inhibitors that effectively reduce the underlying current in vivo or in intact in vitro tissue preparations, and 2) althoug...
متن کاملDistinct Ca2+ Sources in Dendritic Spines of Hippocampal CA1 Neurons Couple to SK and Kv4 Channels
Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and the associated spine head Ca(2+) transient. However, results using glutamate u...
متن کاملParadoxical role of large-conductance calcium-activated K+ (BK) channels in controlling action potential-driven Ca2+ entry in anterior pituitary cells.
Activation of high-conductance Ca(2+)-activated K(+) (BK) channels normally limits action potential duration and the associated voltage-gated Ca(2+) entry by facilitating membrane repolarization. Here we report that BK channel activation in rat pituitary somatotrophs prolongs membrane depolarization, leading to the generation of plateau-bursting activity and facilitated Ca(2+) entry. Such a par...
متن کامل